The key elements of the revised 2020 Vancomycin dosing guidelines include the transition from the trough to an AUC based dosing target and the utilization of Bayesian algorithm to accurately calculate daily AUC values with non-steady-state levels. Bayesian-based precision dosing platforms are essential tools to facilitate the implementation of AUC/MIC-based vancomycin dosing guidelines and optimize clinical practice. PrecisePK is a Bayesian dosing software that has been shown to predict the future vancomycin AUC most accurately in critically ill patients, who are at increased risks of treatment failure due to altered antimicrobial pharmacokinetics2, according to a recently published peer-reviewed study3. Since 1986, we have worked with several renowned institutions such as UC San Diego, UC San Francisco, Sharp Healthcare, etc.
Another study by Mizokami6 [Pai et al 2014] demonstrated the relationship between trough level and AUC. Trough concentrations correlate with significant inter-and intra-variability in the AUC24 exposure; therefore, the vancomycin15-20 mg/L trough concentration range isn’t a reliable indicator of AUC/MIC BMD ratio >400 for S. aureus isolates, which is advocated as a target to achieve clinical effectiveness with vancomycin.