Bug Fixes

• Fixed a bug where Dialysis Entry with the Westra model would display swapped Population and Individual CLrrt values.
  
• Fixed a bug where Sentri7 users could create a new case without selecting a drug.
  
• Fixed a bug where editing a Scr Entry would swap its position to the bottom of the list.
  
• Fixed a bug where Therapeutic Target’s error notification would not be removed.
  

Modifications

• Oracle Health Integration
  
• • Fixed a bug where other drugs were being selected despite selecting Vancomycin as the desired drug.
  • Adjusted Dosage Entry’s infusion time to not be auto-calculated when no value is present from Oracle Health’s API.
  • Adjust MedicationAdministration to only select IV routes as “IV” or “IV Piggyback”.
• Updated any “history entries” returned by the database to generate a unique id using an id generator.
  
• Improved Advanced Analytics performance for larger databases.
  

Bug Fixes

• Fixed a bug where sorting the Patient list by AKI Status would cause the application to crash.
  

Bug Fixes

• Fixed a bug where the patient’s age in months would show an incorrect value.
  

Modifications

• Adjusted PK Parameters to accept and show higher decimal precision for smaller PK values.
  
• Addressed issues related to Cyclosporine and Infliximab citations.
  

Bug Fixes

• Fixed a bug where Tacolimus would be allowed to fit unrealistic Q values by adjusting the fitting algorithm to correctly normalize the loss, leading to more accurate outcomes.
  
• Fixed a bug where Serum Level Graph’s interaction panel would visually overlap its legend.
  
• Fixed a bug where Steady State Analysis was always returning AUC units of hr*mg/L instead of the user’s selected unit when monitoring Busulfan.
  
• Fixed a bug where the Local Population model’s name would incorrectly display the amount of patients used to create the model.
  

Modifications

• Allow users to update Scr Entry value to 100 mg/dL.
  
• Allow users to update CrCl Entry value to 1,000 mL/min.
  
• Allow users to update Serum Entry value to 10,000 ng/mL.
  

Modifications

• Improved Busulfan Bayesian fitting model accuracy for observed trough levels.
  
• Improved Oracle Health (previously Cerner) user experience.
  

Bug Fixes

• Fixed a bug that would cause Serum Level Graph’s fitting settings to not reset properly.
  
• Fixed a bug where CrCl formula would not be displayed after loading a case.
  
• Fixed a bug where the user list on the IAM page would fail to populate.
  
• Fixed a bug where Crass 2018 model would calculate clearance (CL) differently for Exact Crcl History compared to Scr History.
  

New Drug - Cyclosporine

• Cyclosporine is our next transplant drug available for Bayesian forecasting and therapeutic drug monitoring! We now offer three models covering adult and pediatric heart, lung, and kidney patients.
  

New Drug - Infliximab

• Infliximab is our new, much-anticipated immunosuppressant module! Five models are available for Ulcerative colitis, Crohn’s disease, Ankylosing spondylitis, Rheumatoid arthritis, and Psoriasis arthritis patients.
  

Modifications

• Updated Sentri7 integration to allow an existing case to be synchronized with the new incoming data.
  
• Updated Population PK to accept higher levels of decimal precision.
  

Bug Fixes

• Fixed a bug where loading a case with Tacrolimus would freeze the program if Prednisolone Dosage History was left empty.
  
• Fixed a bug where Therapeutic Status Overview would not convert labels to the user’s local timezone.
  
• Fixed a visual bug within Scr History where the layout would not resize correctly when AKI Assessment was disabled.
  
• Fixed a bug where dosing recommendations from the Dosage Regimen Prediction would not automatically import to the Steady State Prediction.
  
• Fixed a visual bug within Scr History where the layout would not resize correctly when AKI Assessment was disabled.
  

New Features

• Updated Timezone Support to fully support multi-timezone clients. This currently applies only to 1) newly created cases and 2) existing cases that are newly loaded and saved.
  

Modifications

• Updated “Search” to persist the user’s input and results. Navigating away or loading a case will no longer clear “Search”.
  

Bug Fixes

• Fixed a bug where Therapeutic Target would fail to generate a recommendation caused by an unsorted Dosage History.
  
• Fixed a bug where Therapeutic Target’s T>MIC% input would not allow users to input values into it.
  
• Fixed a bug where viewing “Last Updated” would display in UTC instead of the user’s local timezone.
  

New Drug Model - Methotrexate

• Methotrexate is our next oncology drug available for Bayesian forecasting and therapeutic drug monitoring! Six models covering Osteosarcoma, Acute Lymphoblastic Leukemia (ALL), Lymphoma, and Rheumatoid Arthritis patients are now available. We hope you find it useful in your everyday practice. New Features
  

New Features

• CrCl History is now available within Lab Results instead of a single CrCl entry! Just like Scr History, the history of CrCl values will be taken into account during PK simulation, dynamically adjusting drug clearance according to the Exact CrCl at each time point.
  
• Multi-site License is available for institutions to access cross-site patient cases and evaluate Advanced Analytics by site. Please contact our team at information@precisepk.com to get started on this!
  
• A new warning set in Drug Monitoring alerts users to increase hydration when a level 12 hours after a dose is above a certain threshold.
  

Modifications

• Improved Drug Monitoring performance to when there are a large number of Dosage/Serum/Dialysis entries.
  
• Added validation tooltips for Lab Result’s Scr and CrCl input fields.
  
• Adjusted Lab Results to no longer clear the input field when the Scr measurement passes the maximum amount.
  
• Updated Print Report to display and export more Therapeutic Target information.
  
• Improved user session security by optimizing user information stored in each session.
  
• Improved keyboard typing and navigation experience.
  

Bug Fixes

• Fixed a bug where Serum Concentration Prediction would sometimes clear its own inputs.
  
• Fixed a bug where non-Vancomycin drugs would sometimes be unable to export results to Steady State Analysis.
  
• Fixed a bug where Dosage Regimen Prediction’s nomogram would be unable to recommend doses with intervals greater than 12.
  
• Fixed a bug where Dosage Regimen Prediction’s inputs would not properly reset when changing the desired route.
  
• Fixed a bug where Serum Level Graph’s time range selection would not render a “check-mark” for the currently selected time range.
  
• Fixed a bug in Print Report where the graph would be shifted outside of the X and Y boundaries.
  
• Fixed a bug in Advanced Analytics where filtering Drug Factors outside of the module would not update the filter.
  
• Adjusted Serum Drug Level’s warning icon, Model Information’s table borders, and color inconsistencies in the Alerts and Dosage Regimen Prediction.
  

New Features

• Dialysis History tooltip is now available to provide clearer guidance and insights into the dialysis workflow! To view, direct to “How do I use Dialysis History?” within Dialysis History.
  
• Therapeutic Target improvements
  

• • In addition to the existing Peak targeting capabilities, our latest update now allows users to conveniently assess both the “Next Peak” and the “Last Peak” in the Dosing Recommendations! “Last Peak” is defined as the predicted peak of the most recent  dose within Dosage History.
  • To further enhance the Therapeutic Target functionality, we have incorporated a “daily max dose warning” feature. This important addition will alert users when the prescribed dosage exceeds the recommended maximum limit on a daily basis.

Modifications

• Strengthened API request error handling stability to ensure smoother operation and increased reliability.
  
• Improved application security to ensure the integrity and confidentiality of user sessions.
  

Bug Fixes

• Fixed a bug where entering Exact CrCl too early with Amikacin would calculate unnecessary warnings.
  
• Fixed a bug where accessing a dose’s analytics prematurely would sometimes cause an error.
  
• Updated a few text/unit inconsistencies throughout the program.
  
• Alerts
  

• • Fixed a bug where Alerts would not properly show alerts related to each record in Dosage History.
  • Fixed a bug where Alerts would not properly group Dosage Regimen Prediction alerts and Serum Concentration Prediction alerts.

• Fixed a bug where updating the drug’s model would sometimes cause the Therapeutic Target to get stuck in a loading animation.
  
• Fixed a bug where adjusting Therapeutic Target’s recommendation would sometimes fail to resolve.
  

New Feature: Auto-Save!

• You asked and we listened! Auto-save was our most requested feature in our 2022 User Survey and we are happy to announce it is now available on the platform. Keep your peace of mind and continue counting on PrecisePK to automate your workflow, helping you bring the best out of your clinical judgment.
  

• PrecisePK will auto-save 5 seconds after your last valid action.
  
• Visit Settings to enable auto-save for yourself or set it to your institution in Admin Settings.
  

Modifications

• Improved program stability for users from non-Latin-based locations.
  

Bug Fixes

• Fixed a bug in Scr History where the CrCL Formula’s name was not displaying properly.
  

Modifications

• Added a "Formula" column in Scr History displaying what CrCl formula is used with each Scr entry.
  

Bug Fixes

• Fixed a bug where users were not able to choose their Organization when selecting "Login with SSO".
  
• Fixed a visual bug on the "Exact CrCl" field during an invalid input.
  

New Integration - Sanford Guide

• Sanford Guide is now accessible within PrecisePK for those with an active subscription! Now, subscribers can enable quick access to drug references and be provided with the most updated guidelines on anti-infective agents and associated diseases. Sanford Guide subscribers can access Sanford Guide through hyperlinks under the Patient Summary and Population PK Source.  
  

New User Interface

• 1. New design, same workflow! While PrecisePK may look a little different than before, the functionality of PrecisePK remains exactly the same. Continue dosing seamlessly with PrecisePK with all the models and features that you know and love.
  2. Updated PrecisePK’s UI by standardizing all styling, colors, and text to a new design system.
  3. New user interface now features improved color contrast, keyboard interactions, and navigation for better viewing and experience.  
  

New Features

• 1. Added "mg/kg" tooltip for Vancomycin dose recommendations. Hover over Vancomycin dose values to show a Tooltip that converts the dose form "mg" to "kg".
  2. Added a Tooltip to Dosage Analytics in Dosage History to provide definitions for all the AUC and Level values to provide clarity into Dosage Analytics' outputs.
  

Modifications

• Streamlined user account permission selection on Identity Access Management. Selecting user roles are now simplified by only allowing one of the three different roles (Admin, User, IAM).
  

Bug Fixes

• 1. Fixed a bug where selecting a drug in Advanced Search would not filter out the other non-selected drugs.
  2. Fixed a bug where “Individual PK From Last Visit” was not populating from previous cases and General Population PK Parameters remained.
  3. Fixed a bug on Advanced Analytics where selecting any non-English language would show placeholder values instead of numbers.
  4. Fixed a bug where the users would lose access to the application, but experience a delay before being redirected to the login page.
  

New Drug Model - Tacrolimus

• Tacrolimus is now available for Bayesian forecasting and therapeutic drug monitoring! Two models covering the adult kidney-transplant population are available to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.
  

New Features

• 1. Introducing the highly anticipated Therapeutic Analytics! This feature categorizes and analyzes how well your patient population achieves your desired Therapeutic Target. Based on the results, patient populations will be categorized into Subtherapeutic, Therapeutic and Supratherapeutic groups.
  
• 2. Users can view and assess these results through Advanced Analytics.
  
• 3. Therapeutic Status Overview provides a breakdown of the number of patients in each therapeutic status, and in different Percentages of Time in Therapeutic Range (%TTR).
  
• 4. Therapeutic Target Insights analyzes the trend of the defined therapeutic target value over a time interval or dose interval.
  
• 5. AKI Analytics is now a part of the Advanced Analytics page.
  

Modifications

• 1. Added the ability to launch SSO directly from PrecisePK login page.
  
• 2. Optimized the Vancomycin Goti 2018 Model to better support ICU patients not on dialysis.
  

Bug Fixes

• 1. Fixed a bug where user could not exit out of the Amputation Options when clicking the “X” icon.
  

New Features

• 1. Added support for Least Squares Fitting for Serum Level Graph Advanced Fittings.
  
• 2. Added Duo SSO Support - PrecisePK can now be integrated with Duo!
  

Modifications

• 1. Performed scheduled maintenance preformed to optimize and upgrade servers..
  
• 2. Optimized Model Analytics to load and graph values more effectively.
  
• 3. Standardized naming on Print Report to match the names of the modules in the application.
  
• 4. Modified Edit History to update according to the user’s timezone.
  
• 5. Optimized user interactions with Serum Level Graph.
  

Bug Fixes

• 1. Fixed a bug where Therapeutic Target would fail to perform analysis on patients with unrealistically long half-lives.
  
• 2. Fixed a bug where Serum Concentration would freeze when clearing intervals for Oral Routes.
  
• 3. Fixed a bug where the Previous Bayesian Model would fail to populate input with a patient’s previous Individual PK Parameter.
  

New Features - Model Analytics Report

• 1. Model Analytics can now be exported as a report! Simply visit the Analytics page and select “Export Analytics Report”.
  

Optimization - “Patient Info” Tab Restructured!

• 1. Patient Information modules re-organized to ease user workflow.
  
• 2. Model Module: Auto-selection of models can now be toggled on/off to allow for manual selection of population models. Recommendation Overlay added to suggest the best fit model for patient.
  

Modifications - Drug Monitoring

• 1. Revamped Current AUC projection and added Future AUC prediction under Dosing Recommendation module to better support clinical workflow. AUIC24 Range updated to Future AUC Prediction, which predicts the next AUC24 after your most recent dose.
  
• 2. Route option now available in Therapeutic Target Input.
  

Modifications - Serum & Dialysis History

• 1. Added unit options of mL/min or mL/hr for Dialysis Flow Rate (Qd) and Hemofiltration Rate (Qhf) in settings.
  
• 2. Added default values for Start Date and Time of Dialysis History to streamline workflow.
  
• 3. Renamed “Serum History” module to “Serum Drug Level” in Drug Monitoring tab.
  

New Features - More Customizable Busulfan Models

• 1. Added both units --- hr*mg/L and min*umol/L for AUC. Now you can select the one that best supports your workflow!
  
• 2. Added AUC cumulative for 2-day regimen as a Therapeutic Target, alongside AUC cumulative for 4-day regimen. The projected AUC range under Dosing Recommendation takes account of the entire dosing regimen.
  

Optimization - Dialysis Module is now showing the Total Clearance

• 1. Added the calculation and display of Cl_tot on Dialysis History card for all types of dialysis.
  

Modification

• 1. IAM users now can resend invitation emails to other users
  

• 2. Added the ability to search patients by their AKI status in the “Advanced Search” on Patient Home
  

• 3. Temporarily disabled “Ethnically Slow Metabolism” from the extra drug factor for further validation.
  

New Feature - Introducing AKI Assessment with Analytics!

• Real-Time Assessment – Assess your patient’s AKI status in real-time through the three most widely adopted AKI classification criteria (KDIGO, RIFLE, and AKIN).
  
• AKI Status Indicator – Your patient's AKI status is now marked with color-coded tags to help you quickly identify and prioritize care.
  
• An Insightful Analytics Dashboard – Perform retrospective assessments and dosing strategies on your institution through multiple data-driven infographics on a consolidated dashboard.
  

Optimization - A More Powerful Serum Level Graph!

• 1. Read levels at any time! – Now you can enter up to two specific dates and times to read and visualize the corresponding Serum levels
  
• 2. Read AUC within any time range! – PrecisePK will automatically calculate the corresponding AUC between the two dates and times you entered.
  
• 3. New Serum Level Graph Tutorial – click on the “ How do I read this graph” at the top right corner and get a thorough walkthrough of the powerful functionalities on this graph
  

Modifications

• 1. Thanks to our users' feedback, we brought back the Current AUIC24 calculation to display on the Therapeutic Target card! You can also click the eye icon next to it to highlight the corresponding area on the Serum Level Graph.
  
• 2. Added an alert banner on top of the Steady Stage page that reminds users that Steady State Analysis does not take account of Dialysis History.
  
• 3. When deleting, archiving or unarchiving a patient, now all cases associated with that patient will be shown in the Edit History table for Admin users.
  
• 4. When selecting from a Dropdown menu (e.g. drug library), now you can search and select options by typing on your keyboard.
  
• 5. Optimized Date and Time input with auto-tabbing.
  
• 6. Increased decimal accuracy of Nomogram (vancomycin) output to from  0 decimal to 1 decimal place.
  

Bug Fixes

• 1.Fixed a bug when targeting AUC cumulative for Busulfan on Therapeutic Target would shown an incorrect date range.
  
• 2. Fixed a bug where Serum Level Graph’s Advanced Fitting Settings “Reset Values” button would reset to the wrong default values for certain drugs.
  
• 3. Fixed a bug where targeting Trough would sometimes incorrectly return the wrong standard deviation.
  
• 4. Updated Voriconazole’s CL citations and the dosing weight for patients with severe fungal infections.
  

New Feature - Introducing Model Analytics

• 1. Model Analytics allows you to compare your patient population’s General Population Models and Bayesian Individual Models for Vancomycin using linear regression. (More drug models to be expected in the future)
  
• 2. Validate each model easily by selecting a predefined statistic: R-Squared, Mean Squared Error, and Normalized Root Mean Square Deviation.
  
• 3. This feature is only available for current customers, please reach out to information@precisepk.com if you’d like to learn more.
  

Modifications

• 1. Added tooltips displaying units in Dosage History, Serum Concentration, and Dialysis History.
  
• 2. Extended simulation to predict serum levels outside the time range of the Serum Level Graph and use them for more accurate dosing regimen recommendations.
  
• 3. Increased Therapeutic Target’s valid Next Dose Date and Time input from 30 days to 60 days after the last dose time.
  
• 4. Labeled the first dose to-be-added as “Loading Dose” on Therapeutic Target card. Bug Fixes
  

Bug Fixes

• 1. Voriconazole Update:
  - Corrected the label of Vmax to Vmax,1 and changed the unit from “mg/day” to “mg/hr” to match the value
  - Updated citations for all PK parameters
  
• 2. Fixed a bug with Phenytoin about steady state values would be calculated even when rate > Vmax
  

Optimization - Introducing New Therapeutic Targeting Workflow!

• Thanks to your feedback, we optimized the drug monitoring workflow so that  now you can evaluate the desired therapeutic target with recommended dosing regimens side by side!
  
• 2. We simplified and streamlined the Dosing Recommendation calculation and user interface. Now you will get recommendation that is most applicable to the next dose.
  
• 3. We redefined the logic to calculate AUC24 to take into account future dosage regimen, as well as dosing history, and individual patient factors.
  
• 4. You are now able to transfer therapeutic target values to the Steady State page with 1-click to receive additional predictive analyses.
  

Modifications

• Added desired AUCQ6 as a therapeutic target for Busulfan.
  
• Added desired AUIC24 as a therapeutic target for Vancomycin with continuous IV route.
  
• Added desired AUC24 as a therapeutic target for Phenytoin.
  
• Added desired Peak, Average Concentration, and Time above MIC% as therapeutic targets for Piperacillin.
  
• Warnings generated specifically on Patient information page will now be displayed in its own sections in the Alerts overlay.
  
• Added Extra Drug Factors and Amputations to both PDF and plain text patient report.
  

Modifications on SSO Account Users

• We’ve made some changes in SSO account users. Now SSO users don’t need to relaunch the application if you are logged out but did not close the browser’s window tab.
  
• SSO users will no longer be able to edit their account settings or invite users through the IAM page.
  

Bug Fixes

• Fixed a bug where archived patient/cases could appear in Recently Active Patient Cases.
  
• Fixed a bug where ALT was not being updated in existing cases.
  

New Feature - Introducing Localization in PrecisePK!

• PrecisePK now enables users to localize the application interface quickly and seamlessly. Users can switch to their preferred language on the login page or on their settings page.
  
• 2. Currently supported languages include:
  
• English
  
• Chinese (中文)
  
• Korean (한국어)
  
• Thai (ไทย)
  
• Spanish (Español)
  
• 3. We continue to improve our product to better support your everyday clinical workflow. If there is a particular language that you wish to see in PrecisePK, please feel free to reach out to our team!
  

Modifications

• We’ve made some changes to the archive and delete feature in PrecisePK. Now administrators can archive, unarchive or delete patient profiles and patient cases on Admin > Patient Database page. Deleted records cannot be recovered. Regular users can only archive patient profiles and cases on the Home page search module.
  
• Redesigned input tooltips on Patient Information and Steady State page to improve user experience in readability.
  
• Overhauled the interaction for date and time input fields to improve user experience to be more predictable and consistent.
  

Bug Fixes

• Resolved an issue where Print Report mislabeled weight and height.
  
• Resolved an issue where “+ Add Dose” in Therapeutic Target would add an invalid Dosage Entry but would not show the invalid UI.
  
• Resolved an issue where targeting Peak & Trough in Therapeutic Target would not show the proper range.
  
• Resolved an issue where updating the phone number input’s nationality through the dropdown would cause an error.
  
• Resolved an issue where Continuous IV would not calculate immediately after entering in a valid input.
  

Modifications

• 1. Updated Busulfan Serum Concentration Unit
  
• Modified Drug Monitoring, Print Report, and Steady-State Analysis Graphs to fit the larger y-axis units.
  
• Changed the unit to ng/mL and the AUC unit to hr*mg/L.
  
• 2. Serum Level Graph Time Range
  
• Serum Level Graph no longer overrides user’s time range choice when it finishes updating.
  
• 3. Clarified Reset Password error message for “Invalid or Expired Verification Code” to help users recover from errors.
  

Bug Fixes

• 1. Fixed a bug where Dosage Regimen Prediction was setting nomogram’s individual interval to population. Causing the recommended individual intervals to be overwritten.
  
• 2. Fixed a UI bug where Westra 2019 model would display the wrong background color for PK Parameter row.
  
• 3. Fixed a bug in Therapeutic Target where targeting Peak & Trough would fail for Vancomycin.
  
• 4. Fixed a bug where the maximum of 60 days warning was not being reset after clearing the Drug Monitoring page.
  

Modifications

• 1. New Request Timeout Fallback for Serum level Graph
  
• Added a new UI overlay on Serum Level Graph when requests have timed out and failed to calculate individual parameters. This would improve the overall stability and performance of the program.
  
• 2. Drug Monitoring
  
• Refined when “Outside of Recommended AUC…” alert in Drug Monitoring would trigger.
  
• Added the ability to automatically sort entries when re-entering the Drug Monitoring page
  
• 3. Serum Concentration Prediction
  
• Added warning to Infusion Time input when infusion time is less than the half-life
  
• 4. Dosage Regimen Prediction
  
• Refined how nomogram decides what interval range to show as default to be more dynamic and practical.
  

Optimizations

• Print Report
  
• Resolved an issue where the “Other notes” section in Print Report would not allow the user to type in non-Latin characters.
  
• 2. Drug Monitoring
  
• Resolved an issue where the x-axis time label would not reflect the actual date and time when entries were unsorted.
  

New Feature: Vancomycin Dialysis Enhancement

New Feature - Continuous Infusion Now Available for Vancomycin

Modifications

• Login & Registration page interface update - increased system status and transparency for user feedback during login, register, and forgot password workflows.
  
• Improved Print Report user interface. Added more dynamic padding for PlainText export and updated the PDF report format to increase readability and consistency.
  
• IAM Page - added more detailed error feedback for Invite User workflows.
  
• Added settings confirmation to program settings and institution settings.
  

Optimizations

• Updated saving logic to detect and prevent duplicate patients.
  
• Voriconazole optimization - increased fitting and graphing speed.
  
• Resolved an issue with oral route fitting slightly off.
  
• Resolved an issue with PK parameters fitting calculation.
  
• Resolved an issue with loading and saving Scr’s value and unit.
  
• Resolved an issue with Gentamicin not fitting correctly.
  

New Features: Vancomycin Model Information

New Feature - User Manual

New Feature - Serum Concentration Alert

New Feature - Edit Scr History on Drug Monitoring

Modifications

• Modified age unit in the Patient Summary section to be more readable (e.g. 5 yr 6 mo instead of 5.5)
  
• Added input validations and tooltips for the Gestational Age input field.
  
• Enhanced user interface and experience on the IAM page when inviting new users and editing their permissions.
  
• Added a dedicated “Source” column in the Population PK card for more information on variables, formulas, modifying factors, and sources. Also updated the sources popup UI to match the new branding.
  
• Changed Vancomycin nomogram default infusion times to 1, 2, and 3 hours for adults.
  
• Updated all terminologies of “CLcr” in the program to “CrCL”.
  

Bug Fixes

• Resolved a few known issues to increase performance stability and consistency.
  

New Drug Model: Busulfan

• Busulfan is now available for Bayesian forecasting and therapeutic drug monitoring! Multiple models available covering different patient populations and drug routes to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.    
  

New Feature - Enhanced User Interface & User Experience

• 1. Introducing patient Home page
  
• Now you can create a new patient, resume patient cases you last worked on, or search from the patient database all from one page.
  
• We added the Recently Active Patient Cases card so you can quickly pick up the patient case you left off without searching for it.
  
• 2. We updated to a simpler navigation structure so you can find everything you need from the top menu bar. If you are a system admin or IAM, use the application switcher to navigate to different modules.
  
• 3. We modified Lab Results Card so now it’s easier to view equations and sources for the calculation
  
• 4. New Info Sidebar on the Drug Monitoring and Steady-State Analysis page - now you can reference all the relevant case information (patient summary and PK parameters) on the left side of the screen while you work through the case.
  

New Feature - Institution Setting

Modifications

• Updated Identity & Access Management (IAM) module with the ability to:
  
• Invite multiple users
  
• Enable, Disable, or Delete users
  
• Edit user permission settings
  
• Changed auto-sort to manual sort when drug monitoring entries are in a non-chronological order.
  
• Enhanced overall security protocols and program performances.
  

Bug Fixes

• Resolved a few known issues to increase stability and consistency.
  

New Features

• Introducing quick select and snap feature to the Serum Level Graph! For patients with longer dosing history, the program will default to select the last 72 hrs of the graphing. You also have the option to quickly select from default views or customize your selection by dragging the side of the gray highlight box.
  

Modifications

• Enhanced security compliances and protocols.
  
• Steady-State Analysis now saves your inputs even after switching pages.
  
• Added additional tooltips and better documentation to PK Parameters, Dosage History, and Serum Level Graph cards.
  
• Updated the default Nomogram intervals from 4/8/12 hr to 6/8/12 hr for the pediatric population.
  
• Increased flexibility in the drug model selection. We’ve opened up more relevant drug options so you can try out different models and predictions as you prefer.
  

Bug Fixes

• Resolved some general UI bugs to increase stability and consistency.
  
• Everything else is fine. (We hope.)
  

New Features

• Added new empty state UI for the PK Parameters card, and N/A state illustration components for Therapeutic Target card and Dosage Regimen Prediction Card when drug targets are not available.
  
• Updated the design for the user profile window. Now you can quickly access your account settings and log out by clicking on your profile initials on the top right corner.
  

Optimization

• Auto-Rounding algorithm is now further refined to be accurate and precise.
  
• Added a “calculation” stage for the Therapeutic Target Recommendation’s confidence interval. When the graph is recalculated, the outdated confidence interval will be replaced with “---” instead.
  

Modifications

• The “Dose Prediction” tab is now renamed as “Steady-State Analysis“ to be more accurate and reflective of its functionalities.
  
• Log Out option is moved from left side navigation to inside the user profile window.
  

Bug Fixes

• Resolved some bugs causing Phenytoin to be unstable.
  
• Resolved a bug where Dosage Regimen Prediction would only import Population data to Serum Concentration Prediction for certain drugs.
  

New Feature - Counter

• Amputations popup link now have an indicator to show the number of amputations selected.
  
• Notes now have an indicator to show the number of notes saved for the current case.
  

Optimization

• “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.
  

Bug Fixes

• Resolved a bug that affected loading specific patient’s birthday.
  
• Resolved a bug that delayed Therapeutic Target re-calculation.
  
• Resolved minor inconsistencies with the Crass 2018 model for Vancomycin.
  
• Resolved a bug where the drug dropdown in the Advanced Search window would not open.
  

New Features

• “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.
  
  

Modifications

• Added PK model option information to the Patient Snapshot card
  
• Modified Serum Concentration Prediction to hide lesser-used prediction values. You will still be able to view this information at your leisure
  
• Standardized AUC nomenclature throughout the program to AUC24/MIC
  
• Refined Add Multiple Doses window workflow for oral routes by disabling the infusion time field
  

Bugs

• Resolved some general UI issues
  
• Resolved a few bugs in Therapeutic Target to be more robust and prevent errors
  
• Resolved a Phenytoin loading bug where Free Fraction % would not calculate
  
• Resolved a bug where Drug Route was not consistent across all PrecisePK modules
  
• Resolved a bug where looking at Individual Dose Analytics would throw an error
  

Optimization

Modifications

• Swapped the locations of the Therapeutic Target card and Serum Level Graph card.
  
• Updated default Vancomycin nomogram interval hours to be 8/12/24.
  
• Automatically fill the MIC to 1 for Vancomycin patient cases.
  
• Added additional tooltips across the program for better transparency support.
  

Bugs

• Resolved a few minor Drug Library issues.
  
• Resolved an issue of using the incorrect weight definition for the Cockcroft-Gault Equation.
  
• Resolved a bug where saving the null PK parameters will cause them to load incorrectly.
  

New Feature - Added counters for Extra Drug Factors and Scr History

Update

• Reordered PK parameters - Only the most important PK parameters will be displayed as default. You can still click on See More to view the entire list.
• Removed Ethnicity drop-down - Added drug factor for African American.

General improvements 

• Improved label consistencies throughout the program
  
• Enabled the option to hide loading dose from the report page
  
• Improved user experience by preventing input errors, improving interaction flows, and better error handling
  

Maintenance and bug fixes

• Resolved a few known bugs (thanks to user feedback!)
  
• Improved server interruption handling to support optimal performance. Now you will be given the option to reconnect or restart the app with auto restored data when server interruption occurs. 
  

New Feature

New Feature - Gestational Age Field

Update - Obesity Class Definitions

Update - Therapeutic Target Changes

Maintenance - Minor bug fixes and UI improvements

• New Notes Window - Compact popup panel that you can access on any page. Leave behind notes for staff coordination and collaboration, and quickly filter through messages via component tags to find relevant information.
• Centralized Alerts - With some feedback from our users, we placed all of the Toxicity Alerts in one place for easy viewing and a more pleasant user experience. See the centralized alerts in the top-right corner under the “Bell” icon.
  
• Auto-sort Drug List - Based on your suggestion, we are making it a little easier for you to select your most used drugs! The drug selection dropdown will now auto-sort based on your use frequency, placing your most used drugs near the top for easy selection.
  
• Resolved some known bugs.
  
• Improved UI styling consistency.
  
• Added tooltips throughout the program for quick reference.
  
• Improved backend structure to support optimal performance.
  

New Feature

New Feature

Maintenance 

• Added additional options for “Infusion Peak Definition” in the Settings page
• Improved UI styling consistency 
• Updated inputs validation UI with tooltip explanations
• Resolved a few known bugs

Maintenance - Minor bug fixes and UI improvements

• Improved UI stability across all supported browsers.
• Improved date format and input consistency.
• Squashed some bugs.

New Feature - Dose Analytics

New Feature - Toxicity Warning

New Feature - Amputation 

New Drug Factors - Obesity and Pharmacogenomics

New Feature - Changelog

Maintenance - Minor bug fixes and UI improvements

• Improved Edge usability when inputting date and time
• New Print Report layout
• More verbose user management with the option to delete users
• New interface to add multiple dosage records
• General UI improvements to the program like new iconography