Changelog

See what’s new in PrecisePK, from major feature releases to minor bug fixes.

February 2021

02/05/2021

New Drug Model: Busulfan

  • Busulfan is now available for Bayesian forecasting and therapeutic drug monitoring! Multiple models available covering different patient populations and drug routes to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.    
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02/05/2021

New Feature - Enhanced User Interface & User Experience

  • 1. Introducing patient Home page
  • Now you can create a new patient, resume patient cases you last worked on, or search from the patient database all from one page.
  • We added the Recently Active Patient Cases card so you can quickly pick up the patient case you left off without searching for it.
  • 2. We updated to a simpler navigation structure so you can find everything you need from the top menu bar. If you are a system admin or IAM, use the application switcher to navigate to different modules.
  • 3. We modified Lab Results Card so now it’s easier to view equations and sources for the calculation
  • 4. New Info Sidebar on the Drug Monitoring and Steady-State Analysis page - now you can reference all the relevant case information (patient summary and PK parameters) on the left side of the screen while you work through the case.
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02/05/2021

New Feature - Institution Setting

  • Thanks for your feedback, now administrative users can set institution-wide general and formula settings for all of the users under their license.
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02/05/2021

Modifications

  • Updated Identity & Access Management (IAM) module with the ability to:
  • Invite multiple users
  • Enable, Disable, or Delete users
  • Edit user permission settings
  • Changed auto-sort to manual sort when drug monitoring entries are in a non-chronological order.
  • Enhanced overall security protocols and program performances.
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02/05/2021

Bug Fixes

  • Resolved a few known issues to increase stability and consistency.
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December 2020

12/08/2020

New Features

  • Introducing quick select and snap feature to the Serum Level Graph! For patients with longer dosing history, the program will default to select the last 72 hrs of the graphing. You also have the option to quickly select from default views or customize your selection by dragging the side of the gray highlight box.
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12/08/2020

Modifications

  • Enhanced security compliances and protocols.
  • Steady-State Analysis now saves your inputs even after switching pages.
  • Added additional tooltips and better documentation to PK Parameters, Dosage History, and Serum Level Graph cards.
  • Updated the default Nomogram intervals from 4/8/12 hr to 6/8/12 hr for the pediatric population.
  • Increased flexibility in the drug model selection. We’ve opened up more relevant drug options so you can try out different models and predictions as you prefer.
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12/08/2020

Bug Fixes

  • Resolved some general UI bugs to increase stability and consistency.
  • Everything else is fine. (We hope.)
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November 2020

11/04/2020

New Features

  • Added new empty state UI for the PK Parameters card, and N/A state illustration components for Therapeutic Target card and Dosage Regimen Prediction Card when drug targets are not available.
  • Updated the design for the user profile window. Now you can quickly access your account settings and log out by clicking on your profile initials on the top right corner.
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11/04/2020

Optimization

  • Auto-Rounding algorithm is now further refined to be accurate and precise.
  • Added a “calculation” stage for the Therapeutic Target Recommendation’s confidence interval. When the graph is recalculated, the outdated confidence interval will be replaced with “---” instead.
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11/04/2020

Modifications

  • The “Dose Prediction” tab is now renamed as “Steady-State Analysis“ to be more accurate and reflective of its functionalities.
  • Log Out option is moved from left side navigation to inside the user profile window.
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11/04/2020

Bug Fixes

  • Resolved some bugs causing Phenytoin to be unstable.
  • Resolved a bug where Dosage Regimen Prediction would only import Population data to Serum Concentration Prediction for certain drugs.
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October 2020

10/19/2020

New Feature - Counter

  • Amputations popup link now have an indicator to show the number of amputations selected.
  • Notes now have an indicator to show the number of notes saved for the current case.
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10/19/2020

Optimization

  • “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.
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10/19/2020

Bug Fixes

  • Resolved a bug that affected loading specific patient’s birthday.
  • Resolved a bug that delayed Therapeutic Target re-calculation.
  • Resolved minor inconsistencies with the Crass 2018 model for Vancomycin.
  • Resolved a bug where the drug dropdown in the Advanced Search window would not open.
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10/08/2020

New Features

  • “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.

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10/08/2020

Modifications

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  • Added PK model option information to the Patient Snapshot card
  • Modified Serum Concentration Prediction to hide lesser-used prediction values. You will still be able to view this information at your leisure
  • Standardized AUC nomenclature throughout the program to AUC24/MIC
  • Refined Add Multiple Doses window workflow for oral routes by disabling the infusion time field
10/08/2020

Bugs

  • Resolved some general UI issues
  • Resolved a few bugs in Therapeutic Target to be more robust and prevent errors
  • Resolved a Phenytoin loading bug where Free Fraction % would not calculate
  • Resolved a bug where Drug Route was not consistent across all PrecisePK modules
  • Resolved a bug where looking at Individual Dose Analytics would throw an error
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September 2020

9/21/2020

Optimization

Implemented a new graphing solution and greatly increased the graphing speed. Now users can enjoy almost instantaneous visualization even with long dosage history.
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9/21/2020

Modifications

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  • Swapped the locations of the Therapeutic Target card and Serum Level Graph card.
  • Updated default Vancomycin nomogram interval hours to be 8/12/24.
  • Automatically fill the MIC to 1 for Vancomycin patient cases.
  • Added additional tooltips across the program for better transparency support.
9/21/2020

Bugs

  • Resolved a few minor Drug Library issues.
  • Resolved an issue of using the incorrect weight definition for the Cockcroft-Gault Equation.
  • Resolved a bug where saving the null PK parameters will cause them to load incorrectly.
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9/11/2020

New Feature - Added counters for Extra Drug Factors and Scr History

Now you can see if any extra drug factors have been automatically selected or more Scr's have been input without opening the dialog window.
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9/11/2020

Update

  • Reordered PK parameters - Only the most important PK parameters will be displayed as default. You can still click on See More to view the entire list.
  • Removed Ethnicity drop-down - Added drug factor for African American.
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9/11/2020

General improvements 

  • Improved label consistencies throughout the program
  • Enabled the option to hide loading dose from the report page
  • Improved user experience by preventing input errors, improving interaction flows, and better error handling
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9/11/2020

Maintenance and bug fixes

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  • Resolved a few known bugs (thanks to user feedback!)
  • Improved server interruption handling to support optimal performance. Now you will be given the option to reconnect or restart the app with auto restored data when server interruption occurs. 

August 2020

8/10/20

New Feature

PrecisePK automatically selects the proper Bayesian models based on your patients’ characteristics. Now, you will also be able to view and select different population models in the dropdown next to the Population PK Parameters, providing greater transparency and user control

When you open the new dropdown, you will be greeted with some new models covering a range of different populations. With the recent release of the 2020 IDSA Vancomycin Guideline, we want to ensure we are fully compliant with these new standards while offering the precision you come to expect from PrecisePK!
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8/10/20

New Feature - Gestational Age Field

We now provide a new field under Patient Info Card to enter the patient’s exact gestational age. This field is triggered when the patient is under 6 months old.
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8/10/20

Update - Obesity Class Definitions

In the Extra Drug Factors, you can now select between three different BMI classes of obesity to further refine the Population model for any obese patients. Hover over each obesity class to see how the program changes the model.
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8/10/20

Update - Therapeutic Target Changes

Based on user feedback, now you can toggle whether the program provides a recommended loading or maintenance dose at your determined date/time. If you like a dosage recommendation, just click “Add Dose” and it will populate under Dosage History. Automatically update target date and time whenever Dosage History updates.
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8/10/20

Maintenance - Minor bug fixes and UI improvements

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  • New Notes Window - Compact popup panel that you can access on any page. Leave behind notes for staff coordination and collaboration, and quickly filter through messages via component tags to find relevant information.
  • Centralized Alerts - With some feedback from our users, we placed all of the Toxicity Alerts in one place for easy viewing and a more pleasant user experience. See the centralized alerts in the top-right corner under the “Bell” icon.
  • Auto-sort Drug List - Based on your suggestion, we are making it a little easier for you to select your most used drugs! The drug selection dropdown will now auto-sort based on your use frequency, placing your most used drugs near the top for easy selection.
  • Resolved some known bugs.
  • Improved UI styling consistency.
  • Added tooltips throughout the program for quick reference.
  • Improved backend structure to support optimal performance.

May 2020

5/1/20

New Feature

This new workflow for the Drug Monitoring page offers flexible dosing recommendations that will help you meet and maintain your desired target.

Additionally, the new dose rounding feature allows instant predictions of efficacy through normal distributions. This new Drug Monitoring page is a dynamic and practical tool for building an effective dose regimen.
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5/1/20

New Feature

Now you can access Product Tours about upcoming new features, which automatically start when you navigate to its respective page for the first time. Product Tours are designed to walk you through workflow changes or larger feature updates, with added visuals for better explanations.
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5/1/20

Maintenance 

  • Added additional options for “Infusion Peak Definition” in the Settings page
  • Improved UI styling consistency 
  • Updated inputs validation UI with tooltip explanations
  • Resolved a few known bugs
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April 2020

4/15/20

Maintenance - Minor bug fixes and UI improvements

  • Improved UI stability across all supported browsers.
  • Improved date format and input consistency.
  • Squashed some bugs.
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4/14/20

New Feature - Dose Analytics

With this new feature, see the properties of each individual dose and its effects on your patient’s serum levels and AUC. Navigate to the Drug Monitoring page, enter a Dosage History record, and see these analytics by clicking the “...” on the record. With more data at your fingertips, it’s easier than ever to analyze the efficacy of your dosage regimen -- dose by dose. 
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4/14/20

New Feature - Toxicity Warning

Throughout the program, a small orange “!” may appear. These are our new Toxicity Warnings, which will pop up whenever PrecisePK detects a potentially toxic dose or level. Detailed explanations are provided when you click on these warnings. You can also view these warnings for individual doses under Dosage History in the Dose Analytics window. 
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4/14/20

New Feature - Amputation 

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Added amputation selection in the patient information card. Now users can select and choose the degree of amputation to further customize PK parameters.

On the Patient Info screen, you are able to adjust the patient’s PK parameters by selecting relevant drug factors or manually entering in the parameters to account for special populations. Now, easily account for amputees with our new Amputation selection, which is placed next to the Drug selection. Select the type of amputation this patient has to automatically adjust the PK parameters and hover over each type of amputation to see how the program adjusts for it. 
4/14/20

New Drug Factors - Obesity and Pharmacogenomics

In addition to the new Amputation selection, we added a couple more drug factors to our list. Account for obese patients and patients with specific genes easily by selecting these new factors.
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4/14/20

New Feature - Changelog

What you are seeing now is our new Changelog feature, which describes any new features, updates, or fixes that are now in the program. We will let you know what has changed whenever you log in for the first time after a recent release, but feel free to check out what’s new by clicking on the [NEW] icon near the top. 
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4/14/20

Maintenance - Minor bug fixes and UI improvements

  • Improved Edge usability when inputting date and time
  • New Print Report layout
  • More verbose user management with the option to delete users
  • New interface to add multiple dosage records
  • General UI improvements to the program like new iconography
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Optimize Your Clinical Experience with PrecisePK.