Changelog

See what’s new in PrecisePK, from major feature releases to minor bug fixes.

June 2021

06/09/2021

New Feature - Introducing Localization in PrecisePK!

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  • PrecisePK now enables users to localize the application interface quickly and seamlessly. Users can switch to their preferred language on the login page or on their settings page.
  • 2. Currently supported languages include:
  • English
  • Chinese (中文)
  • Korean (한국어)
  • Thai (ไทย)
  • Spanish (Español)
  • 3. We continue to improve our product to better support your everyday clinical workflow. If there is a particular language that you wish to see in PrecisePK, please feel free to reach out to our team!
06/09/2021

Modifications

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  • We’ve made some changes to the archive and delete feature in PrecisePK. Now administrators can archive, unarchive or delete patient profiles and patient cases on Admin > Patient Database page. Deleted records cannot be recovered. Regular users can only archive patient profiles and cases on the Home page search module.
  • Redesigned input tooltips on Patient Information and Steady State page to improve user experience in readability.
  • Overhauled the interaction for date and time input fields to improve user experience to be more predictable and consistent.
06/09/2021

Bug Fixes

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  • Resolved an issue where Print Report mislabeled weight and height.
  • Resolved an issue where “+ Add Dose” in Therapeutic Target would add an invalid Dosage Entry but would not show the invalid UI.
  • Resolved an issue where targeting Peak & Trough in Therapeutic Target would not show the proper range.
  • Resolved an issue where updating the phone number input’s nationality through the dropdown would cause an error.
  • Resolved an issue where Continuous IV would not calculate immediately after entering in a valid input.

May 2021

05/12/2021

Modifications

  • 1. Updated Busulfan Serum Concentration Unit
  • Modified Drug Monitoring, Print Report, and Steady-State Analysis Graphs to fit the larger y-axis units.
  • Changed the unit to ng/mL and the AUC unit to hr*mg/L.
  • 2. Serum Level Graph Time Range
  • Serum Level Graph no longer overrides user’s time range choice when it finishes updating.
  • 3. Clarified Reset Password error message for “Invalid or Expired Verification Code” to help users recover from errors.
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05/12/2021

Bug Fixes

  • 1. Fixed a bug where Dosage Regimen Prediction was setting nomogram’s individual interval to population. Causing the recommended individual intervals to be overwritten.
  • 2. Fixed a UI bug where Westra 2019 model would display the wrong background color for PK Parameter row.
  • 3. Fixed a bug in Therapeutic Target where targeting Peak & Trough would fail for Vancomycin.
  • 4. Fixed a bug where the maximum of 60 days warning was not being reset after clearing the Drug Monitoring page.
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05/07/2021

Modifications

  • 1. New Request Timeout Fallback for Serum level Graph
  • Added a new UI overlay on Serum Level Graph when requests have timed out and failed to calculate individual parameters. This would improve the overall stability and performance of the program.
  • 2. Drug Monitoring
  • Refined when “Outside of Recommended AUC…” alert in Drug Monitoring would trigger.
  • Added the ability to automatically sort entries when re-entering the Drug Monitoring page
  • 3. Serum Concentration Prediction
  • Added warning to Infusion Time input when infusion time is less than the half-life
  • 4. Dosage Regimen Prediction
  • Refined how nomogram decides what interval range to show as default to be more dynamic and practical.
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05/07/2021

Optimizations

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  • Print Report
  • Resolved an issue where the “Other notes” section in Print Report would not allow the user to type in non-Latin characters.
  • 2. Drug Monitoring
  • Resolved an issue where the x-axis time label would not reflect the actual date and time when entries were unsorted.

April 2021

04/15/2021

New Feature: Vancomycin Dialysis Enhancement

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We added two new Vancomycin dialysis models (Westra 2019, and Claisse 2019) to account for adult patients on IHD/CRRT. The revamped dialysis module features a new interactive workflow and improved user experience. Vancomycin dialytic clearance, also known as CL_RRT (Previously labeled as Kt/V) will be calculated by the program based on your input. To use these dialysis models, select appropriate factors in the Extra Drug Factors and the program will automatically select the best fitting model.
04/15/2021

New Feature - Continuous Infusion Now Available for Vancomycin

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Users can choose intermittent or continuous IV infusion as the drug route.
04/15/2021

Modifications

  • Login & Registration page interface update - increased system status and transparency for user feedback during login, register, and forgot password workflows.
  • Improved Print Report user interface. Added more dynamic padding for PlainText export and updated the PDF report format to increase readability and consistency.
  • IAM Page - added more detailed error feedback for Invite User workflows.
  • Added settings confirmation to program settings and institution settings.
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04/15/2021

Optimizations

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  • Updated saving logic to detect and prevent duplicate patients.
  • Voriconazole optimization - increased fitting and graphing speed.
  • Resolved an issue with oral route fitting slightly off.
  • Resolved an issue with PK parameters fitting calculation.
  • Resolved an issue with loading and saving Scr’s value and unit.
  • Resolved an issue with Gentamicin not fitting correctly.

March 2021

03/10/2021

New Features: Vancomycin Model Information

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Now you can view detailed Vancomycin Model Information within the program. A quick model summary will pop up when you hover over different model options. Click on the icon next to the model name in the Patient Summary, and you will see detailed model information in a separate popup window.
03/10/2021

New Feature - User Manual

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We added a quick link to the interactive User Manual within the program (under your user profile icon). You will find detailed instructions, video tutorials, and common FAQs – everything you need to get you started with PrecisePK.
03/10/2021

New Feature - Serum Concentration Alert

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We added an alert when the serum concentration was drawn during infusion time, so you can avoid any potential data entry error.
03/10/2021

New Feature - Edit Scr History on Drug Monitoring

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Thanks for your feedback, we now added the ability for users to access and edit Scr History on the Drug Monitoring page (link on the top right corner of the Serum Concentration Card)
03/10/2021

Modifications

  • Modified age unit in the Patient Summary section to be more readable (e.g. 5 yr 6 mo instead of 5.5)
  • Added input validations and tooltips for the Gestational Age input field.
  • Enhanced user interface and experience on the IAM page when inviting new users and editing their permissions.
  • Added a dedicated “Source” column in the Population PK card for more information on variables, formulas, modifying factors, and sources. Also updated the sources popup UI to match the new branding.
  • Changed Vancomycin nomogram default infusion times to 1, 2, and 3 hours for adults.
  • Updated all terminologies of “CLcr” in the program to “CrCL”.
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03/10/2021

Bug Fixes

  • Resolved a few known issues to increase performance stability and consistency.
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February 2021

02/05/2021

New Drug Model: Busulfan

  • Busulfan is now available for Bayesian forecasting and therapeutic drug monitoring! Multiple models available covering different patient populations and drug routes to ensure accurate target attainment in patients undergoing hematopoietic cell transplants (HCTs). We hope you find it useful in your everyday practice.    
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02/05/2021

New Feature - Enhanced User Interface & User Experience

  • 1. Introducing patient Home page
  • Now you can create a new patient, resume patient cases you last worked on, or search from the patient database all from one page.
  • We added the Recently Active Patient Cases card so you can quickly pick up the patient case you left off without searching for it.
  • 2. We updated to a simpler navigation structure so you can find everything you need from the top menu bar. If you are a system admin or IAM, use the application switcher to navigate to different modules.
  • 3. We modified Lab Results Card so now it’s easier to view equations and sources for the calculation
  • 4. New Info Sidebar on the Drug Monitoring and Steady-State Analysis page - now you can reference all the relevant case information (patient summary and PK parameters) on the left side of the screen while you work through the case.
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02/05/2021

New Feature - Institution Setting

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Thanks for your feedback, now administrative users can set institution-wide general and formula settings for all of the users under their license.
02/05/2021

Modifications

  • Updated Identity & Access Management (IAM) module with the ability to:
  • Invite multiple users
  • Enable, Disable, or Delete users
  • Edit user permission settings
  • Changed auto-sort to manual sort when drug monitoring entries are in a non-chronological order.
  • Enhanced overall security protocols and program performances.
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02/05/2021

Bug Fixes

  • Resolved a few known issues to increase stability and consistency.
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December 2020

12/08/2020

New Features

  • Introducing quick select and snap feature to the Serum Level Graph! For patients with longer dosing history, the program will default to select the last 72 hrs of the graphing. You also have the option to quickly select from default views or customize your selection by dragging the side of the gray highlight box.
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12/08/2020

Modifications

  • Enhanced security compliances and protocols.
  • Steady-State Analysis now saves your inputs even after switching pages.
  • Added additional tooltips and better documentation to PK Parameters, Dosage History, and Serum Level Graph cards.
  • Updated the default Nomogram intervals from 4/8/12 hr to 6/8/12 hr for the pediatric population.
  • Increased flexibility in the drug model selection. We’ve opened up more relevant drug options so you can try out different models and predictions as you prefer.
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12/08/2020

Bug Fixes

  • Resolved some general UI bugs to increase stability and consistency.
  • Everything else is fine. (We hope.)
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November 2020

11/04/2020

New Features

  • Added new empty state UI for the PK Parameters card, and N/A state illustration components for Therapeutic Target card and Dosage Regimen Prediction Card when drug targets are not available.
  • Updated the design for the user profile window. Now you can quickly access your account settings and log out by clicking on your profile initials on the top right corner.
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11/04/2020

Optimization

  • Auto-Rounding algorithm is now further refined to be accurate and precise.
  • Added a “calculation” stage for the Therapeutic Target Recommendation’s confidence interval. When the graph is recalculated, the outdated confidence interval will be replaced with “---” instead.
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11/04/2020

Modifications

  • The “Dose Prediction” tab is now renamed as “Steady-State Analysis“ to be more accurate and reflective of its functionalities.
  • Log Out option is moved from left side navigation to inside the user profile window.
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11/04/2020

Bug Fixes

  • Resolved some bugs causing Phenytoin to be unstable.
  • Resolved a bug where Dosage Regimen Prediction would only import Population data to Serum Concentration Prediction for certain drugs.
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October 2020

10/19/2020

New Feature - Counter

  • Amputations popup link now have an indicator to show the number of amputations selected.
  • Notes now have an indicator to show the number of notes saved for the current case.
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10/19/2020

Optimization

  • “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.
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10/19/2020

Bug Fixes

  • Resolved a bug that affected loading specific patient’s birthday.
  • Resolved a bug that delayed Therapeutic Target re-calculation.
  • Resolved minor inconsistencies with the Crass 2018 model for Vancomycin.
  • Resolved a bug where the drug dropdown in the Advanced Search window would not open.
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10/08/2020

New Features

  • “Hold the dose“ feature in Dose Regimen Prediction is now more optimized and more practical.

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10/08/2020

Modifications

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  • Added PK model option information to the Patient Snapshot card
  • Modified Serum Concentration Prediction to hide lesser-used prediction values. You will still be able to view this information at your leisure
  • Standardized AUC nomenclature throughout the program to AUC24/MIC
  • Refined Add Multiple Doses window workflow for oral routes by disabling the infusion time field
10/08/2020

Bugs

  • Resolved some general UI issues
  • Resolved a few bugs in Therapeutic Target to be more robust and prevent errors
  • Resolved a Phenytoin loading bug where Free Fraction % would not calculate
  • Resolved a bug where Drug Route was not consistent across all PrecisePK modules
  • Resolved a bug where looking at Individual Dose Analytics would throw an error
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September 2020

9/21/2020

Optimization

Implemented a new graphing solution and greatly increased the graphing speed. Now users can enjoy almost instantaneous visualization even with long dosage history.
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9/21/2020

Modifications

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  • Swapped the locations of the Therapeutic Target card and Serum Level Graph card.
  • Updated default Vancomycin nomogram interval hours to be 8/12/24.
  • Automatically fill the MIC to 1 for Vancomycin patient cases.
  • Added additional tooltips across the program for better transparency support.
9/21/2020

Bugs

  • Resolved a few minor Drug Library issues.
  • Resolved an issue of using the incorrect weight definition for the Cockcroft-Gault Equation.
  • Resolved a bug where saving the null PK parameters will cause them to load incorrectly.
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9/11/2020

New Feature - Added counters for Extra Drug Factors and Scr History

Now you can see if any extra drug factors have been automatically selected or more Scr's have been input without opening the dialog window.
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9/11/2020

Update

  • Reordered PK parameters - Only the most important PK parameters will be displayed as default. You can still click on See More to view the entire list.
  • Removed Ethnicity drop-down - Added drug factor for African American.
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9/11/2020

General improvements 

  • Improved label consistencies throughout the program
  • Enabled the option to hide loading dose from the report page
  • Improved user experience by preventing input errors, improving interaction flows, and better error handling
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9/11/2020

Maintenance and bug fixes

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  • Resolved a few known bugs (thanks to user feedback!)
  • Improved server interruption handling to support optimal performance. Now you will be given the option to reconnect or restart the app with auto restored data when server interruption occurs. 

August 2020

8/10/20

New Feature

PrecisePK automatically selects the proper Bayesian models based on your patients’ characteristics. Now, you will also be able to view and select different population models in the dropdown next to the Population PK Parameters, providing greater transparency and user control

When you open the new dropdown, you will be greeted with some new models covering a range of different populations. With the recent release of the 2020 IDSA Vancomycin Guideline, we want to ensure we are fully compliant with these new standards while offering the precision you come to expect from PrecisePK!
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8/10/20

New Feature - Gestational Age Field

We now provide a new field under Patient Info Card to enter the patient’s exact gestational age. This field is triggered when the patient is under 6 months old.
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8/10/20

Update - Obesity Class Definitions

In the Extra Drug Factors, you can now select between three different BMI classes of obesity to further refine the Population model for any obese patients. Hover over each obesity class to see how the program changes the model.
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8/10/20

Update - Therapeutic Target Changes

Based on user feedback, now you can toggle whether the program provides a recommended loading or maintenance dose at your determined date/time. If you like a dosage recommendation, just click “Add Dose” and it will populate under Dosage History. Automatically update target date and time whenever Dosage History updates.
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8/10/20

Maintenance - Minor bug fixes and UI improvements

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  • New Notes Window - Compact popup panel that you can access on any page. Leave behind notes for staff coordination and collaboration, and quickly filter through messages via component tags to find relevant information.
  • Centralized Alerts - With some feedback from our users, we placed all of the Toxicity Alerts in one place for easy viewing and a more pleasant user experience. See the centralized alerts in the top-right corner under the “Bell” icon.
  • Auto-sort Drug List - Based on your suggestion, we are making it a little easier for you to select your most used drugs! The drug selection dropdown will now auto-sort based on your use frequency, placing your most used drugs near the top for easy selection.
  • Resolved some known bugs.
  • Improved UI styling consistency.
  • Added tooltips throughout the program for quick reference.
  • Improved backend structure to support optimal performance.

May 2020

5/1/20

New Feature

This new workflow for the Drug Monitoring page offers flexible dosing recommendations that will help you meet and maintain your desired target.

Additionally, the new dose rounding feature allows instant predictions of efficacy through normal distributions. This new Drug Monitoring page is a dynamic and practical tool for building an effective dose regimen.
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5/1/20

New Feature

Now you can access Product Tours about upcoming new features, which automatically start when you navigate to its respective page for the first time. Product Tours are designed to walk you through workflow changes or larger feature updates, with added visuals for better explanations.
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5/1/20

Maintenance 

  • Added additional options for “Infusion Peak Definition” in the Settings page
  • Improved UI styling consistency 
  • Updated inputs validation UI with tooltip explanations
  • Resolved a few known bugs
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April 2020

4/15/20

Maintenance - Minor bug fixes and UI improvements

  • Improved UI stability across all supported browsers.
  • Improved date format and input consistency.
  • Squashed some bugs.
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4/14/20

New Feature - Dose Analytics

With this new feature, see the properties of each individual dose and its effects on your patient’s serum levels and AUC. Navigate to the Drug Monitoring page, enter a Dosage History record, and see these analytics by clicking the “...” on the record. With more data at your fingertips, it’s easier than ever to analyze the efficacy of your dosage regimen -- dose by dose. 
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4/14/20

New Feature - Toxicity Warning

Throughout the program, a small orange “!” may appear. These are our new Toxicity Warnings, which will pop up whenever PrecisePK detects a potentially toxic dose or level. Detailed explanations are provided when you click on these warnings. You can also view these warnings for individual doses under Dosage History in the Dose Analytics window. 
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4/14/20

New Feature - Amputation 

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Added amputation selection in the patient information card. Now users can select and choose the degree of amputation to further customize PK parameters.

On the Patient Info screen, you are able to adjust the patient’s PK parameters by selecting relevant drug factors or manually entering in the parameters to account for special populations. Now, easily account for amputees with our new Amputation selection, which is placed next to the Drug selection. Select the type of amputation this patient has to automatically adjust the PK parameters and hover over each type of amputation to see how the program adjusts for it. 
4/14/20

New Drug Factors - Obesity and Pharmacogenomics

In addition to the new Amputation selection, we added a couple more drug factors to our list. Account for obese patients and patients with specific genes easily by selecting these new factors.
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4/14/20

New Feature - Changelog

What you are seeing now is our new Changelog feature, which describes any new features, updates, or fixes that are now in the program. We will let you know what has changed whenever you log in for the first time after a recent release, but feel free to check out what’s new by clicking on the [NEW] icon near the top. 
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4/14/20

Maintenance - Minor bug fixes and UI improvements

  • Improved Edge usability when inputting date and time
  • New Print Report layout
  • More verbose user management with the option to delete users
  • New interface to add multiple dosage records
  • General UI improvements to the program like new iconography
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Optimize Your Clinical Experience with PrecisePK.